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Xenobiotic-mediated activation of the aryl hydrocarbon receptor (AHR) is immunotoxic in a number of immune cell types, with the B cell being a well-established sensitive target. Recent advances have provided evidence that the B cell repertoire is a heterogeneous population, with subpopulations exhibiting vastly different cellular and functional phenotypes. Recent work from our laboratory identified the T cell specific kinase lck as being differentially regulated by  2,3,7,8-tetrachlorodibenzo-p-dioxin  (TCDD), which is a potent activator of AHR. While LCK is primarily expressed in T cells, a subset of CD5 +  B cells also express LCK. CD5 positivity describes a broad class of B lymphocytes termed innate-like B cells (ILBs) that are critical mediators of innate immunity through constitutive secretion of polyvalent natural immunoglobulin M (IgM). We hypothesized that CD5 +  ILBs may be sensitive to AHR-mediated immunotoxicity. Indeed, when CD5 +  B cells were isolated from the CD19 +  pool and treated with TCDD, they showed increased suppression of the CD40 ligand-induced IgM response compared to CD5 -  B cells. Further, characterization of the CD5 +  population indicated increased basal expression of  AHR , AHR repressor ( AHRR ), and cytochrome p450 family 1 member a1 ( CYP1A1 ). Indeed the levels of AHR-mediated suppression of the IgM response from individual donors strongly correlated with the percentage of the B cell pool that was CD5 + , suggesting that CD5 +  B cells are more sensitive to AHR-mediated impairment. Together these data highlight the sensitive nature of CD5 +  ILBs to AHR activation and provide insight into mechanisms associated with AHR activation in human B cells.

Identification of a Sensitive Human Immunological Target of Aryl Hydrocarbon Receptor Activation: CD5+ Innate-Like B Cells