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The discovery that the Duffy antigen was a promiscuous chemokine binding protein was entirely serendipitous and resulted from research begun at Genentech in 1991. The company had a strong interest in chemokines because of their role in disease and this was furthered by the recent cloning of two chemokine receptors CXCR1 and CXCR2. Both were IL-8 (CXCL8) receptors expressed on immune cells, primarily neutrophils, and belonged to the G-protein coupled receptor (GPCR) subfamily, which were highly druggable targets. Numerous reports linked CXCL8 to respiratory diseases like COPD, and Genentech had developed a CXCL8 neutralizing antibody that it thought might be useful therapeutically to treat respiratory diseases like emphysema, bronchitis, and COPD.

The Duffy Antigen Receptor for Chemokines DARC/ACKR1