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Objective  The current study was conducted to determine whether peak bone mineral density (BMD) and obesity phenotypes are associated with certain  LGR4  gene polymorphisms found in Chinese nuclear families with female children.    Methods  A total of 22 single nucleotide polymorphisms (SNPs) located in and around the  LGR4  gene were identified in 1,300 subjects who were members of 390 Chinese nuclear families with female children. Then, BMD readings of the femoral neck, total hip, and lumbar spine as well as measurements of the total lean mass (TLM), total fat mass (TFM), and trunk fat mass were obtained  via  dual-energy X-ray absorptiometry. The quantitative transmission disequilibrium test was used to analyze the associations between specific SNPs and  LGR4  haplotypes and peak BMD as well as between  LGR4  haplotypes and TLM, percent lean mass, TFM, percent fat mass, trunk fat mass, and body mass index (BMI).    Results  Here, rs7936621 was significantly associated with the BMD values for the total hip and lumbar spine, while rs10835171 and rs6484295 were associated with the trunk fat mass and BMI, respectively. Regarding the haplotypes, we found significant associations between GAA in block 2 and trunk fat mass and BMI, between AGCGT in block 3 and total hip BMD, between TGCTCC in block 5 and femoral neck BMD, and between TACTTC in block 5 and both lumbar spine and femoral neck BMD (all  P -values < 0.05).    Conclusion  Genetic variations of the  LGR4  gene are related to peak BMD, BMI, and trunk fat mass.

LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families