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The opportunistic human pathogen  Pseudomonas aeruginosa  is responsible for a variety of acute infections and is a major cause of mortality in chronically infected patients with cystic fibrosis (CF). Considering the intrinsic and acquired resistance of  P. aeruginosa  to currently used antibiotics, new therapeutic strategies against this pathogen are urgently needed. Whereas virulence factors of  P. aeruginosa  are well characterized, the interplay between  P. aeruginosa  and the innate immune response during infection remains unclear. Zebrafish embryo is now firmly established as a potent vertebrate model for the study of infectious human diseases, due to strong similarities of its innate immune system with that of humans and the unprecedented possibilities of non-invasive real-time imaging. This model has been successfully developed to investigate the contribution of bacterial and host factors involved in  P. aeruginosa  pathogenesis, as well as rapidly assess the efficacy of anti- Pseudomonas  molecules. Importantly, zebrafish embryo appears as the state-of-the-art model to address  in vivo  the contribution of innate immunity in the outcome of  P. aeruginosa  infection. Of interest, is the finding that the zebrafish encodes a CFTR channel closely related to human CFTR, which allowed to develop a model to address  P. aeruginosa  pathogenesis, innate immune response, and treatment evaluation in a CF context.

Zebrafish Embryo Infection Model to Investigate Pseudomonas aeruginosa Interaction With Innate Immunity and Validate New Therapeutics