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Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E ( 1 ) and F ( 2 ), one new chromone fusarimone A ( 5 ), two new benzofurans fusarifurans A ( 9 ) and B ( 10 ), three new isocoumarins fusarimarins A–C ( 11–13 ), as well as five known analogues  3 ,  4 ,  6–8  and  14  were isolated from mangrove endophytic fungus  Fusarium  sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds  1  and  2  showed significant cytotoxicity against human A549 cell lines with IC 50  values of 8.7 and 4.3 μM, respectively.

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2