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Angucyclines and angucyclinones represent the largest family of type II PKS-engineered natural products. Chemical analysis of a marine  Streptomyces  sp. KCB-132 yielded three new members, actetrophenone A (1) and actetrophenols A–B (2–3). Their structures were elucidated by NMR spectroscopy, X-ray crystallography and CD calculations. Actetrophenone A (1) is the first representative of a novel-type angucyclinone bearing a nonaromatic D-ring. Actetrophenol A (2) features a highly reduced and aromatized four-ring system, which is unprecedented for natural products. While ( Ra   )- and ( Sa   )-actetrophenol B (3) bear an unprecedented  N -acetyltryptamine-substituted tetraphene core skeleton, this is the first report of a pair of atropisomeric isomers in the angucyclinone family. Actetrophenol A (2) exhibits remarkable antibiotic activity, notably including potent activity to multiple resistant  Staphylococcus aureus  and  Enterococcus faecium  with MIC values of 4 μg/ml, in contrast, the positive control antimicrobial agent penicillin was inactive up to 32 μg/ml.

Ring D-Modified and Highly Reduced Angucyclinones From Marine Sediment-Derived Streptomyces sp.