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A series of novel 1 H -1,2,3-triazole analogs ( 9a–j ) were synthesized  via “Click”  chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity  in vitro . The synthesis of triazole  7a  was accomplished using ( S )-(-) ethyl lactate as a starting material. This compound ( 7a)  underwent Suzuki–Miyaura cross-coupling reaction with different arylboronic acids in aqueous medium to afford the target molecules,  9a–j  in good yields. All newly synthesized compounds were characterized by  1 H NMR,  13 C NMR, FT-IR, HRMS, and where applicable  19 F NMR spectroscopy ( 9b ,  9e ,  9h , and  9j ). The new compounds have shown moderate inhibition potential against carbonic anhydrase-II enzyme. A preliminary structure-activity relationship suggested that the presence of polar group at the 1 H -1,2,3-triazole substituted phenyl ring in these derivatives ( 9a–j ) has contributed to the overall activity of these compounds. Furthermore,  via  molecular docking, it was deduced that the compounds exhibit inhibitory potential through direct binding with the active site residues of carbonic anhydrase-II enzyme. This study has unraveled a new series of triazole derivatives as good inhibitors against carbonic anhydrase-II.

Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via “Click” Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors