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Administration of sedation is a common practice in most of the clinical and/or surgical interventions, especially in critical care environment. Although it is necessary to relieve critically ill patients from unpleasant physical and psychological experiences, continuous assessment of sedation is highly crucial as improper sedation practice may lead to serious complications such as delirium. To deal with these concerns, bio-markers for sedative-induced unconsciousness must be manifested through objective brain signal analyses. A balanced amalgamation of cortical integration and differentiation has been proposed by several theoretical developments in the field of consciousness, which involve substantial variations in information transfer networks across multiple scales (Tononi, 2004). These findings motivate further research to correlate these variations with altered states of consciousness and quantify them. In this work, Partial Granger Causality (PGC) (Guo et al., 2008) has been utilised to assess the effect of sedation on the Fronto-Centro-Parietal cortical network.

Effective Connectivity Analysis in Fronto-Centro-Parietal Network during Altered Levels of Consciousness