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In the present work, ligand-based drug design approach viz. consensus pharmacophoric analysis has been executed for antimycobacterial DprE1 inhibitory activity of substituted hydantoins to find out the associated important features for future optimizations. The methodology involves structure drawing, optimization, filed-based alignment and construction of pharmacophore model. The study point outs that H-bond donor and acceptor groups as well as aromatic rings are vital for the anti-malarial activity. The outcomes could be advantageous for optimization of 2anilino 4-amino substituted quinazolines as anti-malarial agents.

Consensus Pharmacophore identification for antimycobacterial DprE1 inhibitory activity of substituted hydantoins.