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The present study was undertaken to investigate the effect of presence of hydrophilic polymer on the complexation efficiency of cyclodextrins and solubility of quercetin. The phase solubility studies were carried out in presence and absence of hydrophilic polymers (hydroxypropylmethylcellulose, polyvinylpyrrolidone K30 and poloxamer 188) to study their effect on the stability and complexation efficiency of CDs. The phase solubility studies revealed the formation of QUN-βCD and QUN-HPβCD complexes with 1:1 stoichiometry. The incorporation of POLO increased the stability as well as complexation efficiency of CDs.

Phase Solubility Study of Quercetin in Presence of Cyclodextrins and Hydrophilic Polymers.