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Background: Chondrocyte apoptosis has been known playing a role in knee osteoarthritis (KOA) pathomechanism. Survivin is a survival protein which is believed to be involved in cellular division and prevention of cell death. Unfortunately, there are lack of studies exploring the role and profile of survivin in osteoarthritic knee joints. Objectives: To study about the profile of circulating level of survivin and its correlations with several indicators related to primary KOA. Materials and Methods: This is a cross-sectional study in primary KOA. Subjects are consecutively collected. Anamnesis, physical and laboratory examination, also knee radiographs were performed to determine KOA severity, knee pain severity, the presence of other joint OA instead of KOA, overweight, diabetes mellitus (DM), hyperuricaemia and OA medication. Plasma level of survivin was measured with ELISA method. The correlations between high plasma survivin level with KOA severity, knee pain severity and the presence of overweight were determined separately using Spearman’s correlation tests. Multivariate linier regression test was done to find out the association of high plasma survivin level with all variables related to knee OA (α=0.05). Results: There were no significant correlation between high plasma survivin level with KOA severity or knee pain severity (p>0.05), although an inverse non-significant correlation showed by KOA severity (r= -0.03) and knee pain severity (r= -0.08) with high plasma survivin level. Only overweight and high plasma survivin level gave a significant positive correlation (r=0.36; p=0.03). Gender, presence of other joint OA, DM, hyperuricaemia, OA medication showed insignificant association with high plasma survivin level (p>0.05). Conclusion: In primary KOA patients, knee OA severity and knee pain severity showed no significant correlation with high plasma survivin level, but overweight had a significant positive correlation with high plasma survivin level.

Profile and Association of Circulating Survivin Level with Several Indicators of Knee Osteoarthritis