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Bio-inspired strategy is kind of interesting to fabricate devices and perform dynamic operations [1]. Various devices have been made, such as airplane, radar and submarine. In life science, as the fundamental entity, million years’ evolution enables cell becomes the most successful functionality. Thus, cell studies undoubtedly deepen our understanding of living systems, and it further bring some predesigned functionalities in living systems [2]. Since Thomas Chang demonstrated the feasibility of artificial cells, scientists have constructed a number of artificial cell-like systems for mimicking cellular molecular signaling [3]. It requires at least three key components towards engineering artificial cell: (i) a metabolic machinery that captures energy and resources for cell living; (ii) a membrane component that keeps the living entity stable and separated from the environment; (iii) a genetic system that processes and transfers information heritance [4,5].

DNA Nanotechnology Engineered Vesicle for Mimicking Biomolecular Signaling