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Background: To determine the relation between chromosomal abnormality trisomy 21 and trisomy 18 in the pregnancy with respect to maternal age. Materials and Methods: This was a screening study for trisomy 21 and 18 by a combination of maternal age, maternal serum biochemistry and foetal Nuchal Translucency (NT) and crownrump length (CRL), conducted at one of the south Indian private medical college, Kerala. We screened 88 pregnant women during their 11-14 weeks of pregnancy from 10 February 2019 to 10 August 2020. Results: The study included 86 singleton pregnancies and 2 twin pregnancies, mean age 26.53(SD±5.2), 74% were between 21-30 years of age and majority of them from 12 weeks of their pregnancy. In this study the mean CRL was 58.3(SD±10) and 5.7% (n=5) were chromosomally abnormal among this two were positive for Downs syndrome 60% (n=3), one was trisomy-18 20% (n=2), Nuchal translucency (NT) and age (P= 0.00: R =0.477), crownrump length and age (P= 0.041: R =-0.219) have an association. The study shows an association with chromosomal abnormality with age (P= 0.00: R =0.00), NT (P= 0.00: R =0.00) and it has a correlation with CRL (R=0.00), free β-hCG (R=0.00).

Screening for trisomy 21by maternal age, maternal serum biochemistry and nuchal translucency at 11-14 weeks of pregnancy: A South Indian study