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Background Objective: To compare the effect of preemptive administration of IV Nefopam versus Paracetamol as postoperative analgesia in patients undergoing vaginal wall repairs under spinal anesthesia. Materials and Methods: 120 adult female patients, aged 15-50 years, ASA physical status Ι and ΙΙ were scheduled for anterior and posterior vaginal wall repair (APR) and assigned in a randomized manner into three groups after spinal anesthesia. In control group, 50 ml of normal saline had been infused intravenously over 15 minutes. In group (P), an intravenous infusion of 1 g paracetamol had been given over 15 minutes. In group (N), an intravenous infusion of 20 mg nefopam in 50 ml normal saline had been given over 15 minutes. Visual analogue scale (VAS) was take at constant times postoperatively and the total requested postoperative dose of tramadol had been calculate. Results: Both paracetamol and nefopam groups are associated with a significant longer time to first request of postoperative analgesic treatment (group N ˃ P ˃ C) (P < 0.05) with a significant reduction in the total required postoperative analgesics. VAS revealed a significantly lower score in Group N and P, compared to group C. Conclusion: Preemptive IV paracetamol and nefopam is a good plan to provide an effective postoperative analgesia following spinal anesthesia in patients undergoing vaginal APR.

international journal of medical anesthesiology

The effect of preemptive administration of IV nefopam versus paracetamol as postoperative analgesia in women undergoing vaginal wall repairs under spinal anesthesia. (A comparative study)