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Hypotension during spinal anaesthesia is because of the physiologic effects of central Neuraxial blockade, which is due to two major alterations in cardiovascular systems. First is blockade of sympathetic vasoconstrictor Fibers of the arterioles. Arteriolar dilatation results in a decrease in peripheral vascular resistance. The second is actual dilatation of peripheral veins and Venules with pooling of blood. This combined with paralysis of skeletal muscle and the loss of muscular milking action plus the interference with the thoracic respiratory pump decreases venous return. Sixty patients in the age group between 20 and 60 years belonging to ASA Grade-I and Grade-II posted for elective lower limb surgeries were grouped randomly into two groups(n=30). Randomization was done using simple sealed envelope technique. Based on outcome variables namely mean sensory and motor block time, significance detection of mean difference of 20 minutes, with 90% statistical power and 5% level of significance, the sample of 60 was adequate. There was a statistically significant changes in the pulse rate between two groups during first 60 minutes. Two patients in Group LD had bradycardia and no patients in Group LF. There is no statistically significant difference in systolic blood pressure between the groups. Two patients in Group L and Two patients in Group LD had hypotension. Two patients in Group L developed adverse effects (Bradycardia-2), and Four patients in Group LD (Hypotension –2, Bradycardia – 2). There was no statistically significant difference between the groups regarding adverse effects (p=0.671).

international journal of medical anesthesiology

A study on hemodynamic changes and adverse reactions between isobaric levobupivacaine 0.5% versus isobaric levobupivacaine 0.5% with 3mcg dexmeditomidine