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The application of a single high dose of Dexmedetomidine reduced norepinephrine release by as much as 92% in young healthy volunteers. The release of epinephrine is also reduced by the same amount . The baroreceptor reflex is well preserved in patients who received Dexmedetomidine, and the reflex heart rate response to a pressor stimulus is augmented. These results illustrate that cardiovascular response is evoked mainly by decrease in central sympathetic outflow. After clinical approval of Institutional Ethical Committee Clearance and informed written consent of 90 patients of ASA physical class I and II who were posted for elective Total Abdominal Hysterectomy (TAH). The study population was randomly selected based on the closed sealed opaque envelope technique. The mean duration of surgery in Group-B was 61.00±13.60min, Group-D was 66.33±12.79min and Group-F was 67.33±10.72min. There was no statistically significant difference in the mean duration of surgery among three groups (P>0.05). Statistically there was no significant difference in DBP (mm of Hg) measured at various intervals throughout the surgery among the groups (P>0.05).

international journal of medical anesthesiology

Comparison of hemodynamic changes between intrathecal dexzmedetomidine 5µg and Fentanyl 25µg as adjuvants to 12.5mg of 0.5% hyperbaric bupivacaine for spinal anesthesia