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Background: Helicobacter pylori (HP) infection is the most common infection in the world. It was associated with many gastrointestinal and extra-gastrointestinal diseases. There was evidence of strong association between H.pylori infection and Diabetes Mellitus, especially Type 2 DM. Objectives: The aim of our study was to investigate the relationship between severity of Helicobacter Pylori induced gastritis and glycemic control in patients with type 2 diabetis. Patients and methods: Fifty type 2 diabetic male patients (mean age 47.50 ± 6.01years) were admitted to gastroenterology unit of the Alexandria Main University Hospital for upper gastrointestinal endoscopy. Thirty of them are H.pylori positive (cases) and twenty were H.pylori negative (controls). Following data were collected from all patients: BMI, waist circumference, CBC, liver enzymes, urea, creatinine, Hemoglobin A1c level, fasting blood glucose. Also biopsy specimens were obtained to Diagnose H.pylori by rapid urease test and to assess severity of gastritis histopathologically by Updated Sydney Score. Result: comparison between the two studied groups according to age, BMI, ESR, liver enzymes and creatinine showed no significant difference while hemoglobin, platete count, blood urea showed significant difference between the two groups. Although fasting blood glucose showed no statistically significant difference, Hemoglobin A1c showed significant difference between the two groups (p<0.001). There was a statistically significant relationship between hemoglobin A1C and the severity of H.pylori inflammation in cases group (p<0.001). Levels of Hb A1C were positively correlated with neutrophil infiltration, chronic inflammation, glandular atrophy and intestinal metaplasia in histopathology samples from cases group. Conclusions: Helicobacter Pylori infection and severity of H.pylori induced gastritis correlate with higher levels of Hb A1C in type 2 diabetic patients.

Relation Between Severity of Helicobacter Pylori Induced Gastritis and Glycemic Control in Egyptian Male Patients with Type-2 Diabetes Mellitus