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Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], was extracted form turmeric and also synthesized by the condensat ion of vanillin substituted by acetyl acetone. Its metal complexes (M = Eu, Ce, La, Y, Cr , Pd) were prepared and characterized by IR and UV-vis spectroscopy. The result shows that curcumin coordinates with metal ions in bidentate mode in deprotonated form. Anti-bacter ial study of the synthesized complexes indicated that this complexes has anti-bacterial ac tivity against Klebsiella pneumonia and Escherichia coli. The result of agarose gel electro phoresis suggested that the complexes had good interaction with genomic DNA.

journal of scientific research

Synthesis and Characterization of Metal Complexes Containing Curcumin (C&lt;sub&gt;21&lt;/sub&gt;H&lt;sub&gt;20&lt;/sub&gt;O&lt;sub&gt;6&lt;/sub&gt;) and Study of their Anti-microbial Activities and DNA-binding Properties