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Andrographis paniculata (Family: Acanthaceae), usually known as Kalmegh or King of Bitters, is a bitter annual herb commonly found in the plain lands of Bangladesh, India, Sri Lanka and West Indies. It is extensively used as home remedy for various diseases in Ayurvedic, Unani, Siddha as well as tribal medicines. The plant is beneficial to liver disorders, common cold, upper respiratory tract infection and also cools and relieves internal heat, inflammation and pain. The main bitter constituents of the plant are labdane type diterpene lactones namely andrographolide, neoandrographolide, 14-deoxy11,12-didehydroandrographolide, 14-deoxy-11-oxoandrographolide and 14-deoxyandrographolide. Previous reports suggested that andrographolide-type compounds possess strong antimicrobial activity against several organisms. The present study was designed to isolate antimicrobial compounds from the ethanolic extract of the leaves and stems of A. paniculata. We, herein, report the isolation of 14deoxyandrographolide and its antimicrobial activities against two clinical bacterial species collected from local diagnostic centers namely Salmonella typhi and Escherichia coli. The leaves and stems of the plant were collected from the Medicinal Plant Garden, Faculty of Pharmacy, University of Dhaka in September, 2017 and identified as Andrographis paniculata (Family:

14-Deoxyandrographolide Isolated from Andrographis paniculata (Burm. f) Nees Growing in Bangladesh and its Antimicrobial Properties