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Typhoid fever still continues to be a major public health problem, particularly in many developing countries. A simple, reliable, affordable and rapid diagnostic test has been a long-felt need of the clinicians. We, therefore, prospectively evaluated the sensitivity and specificity of Typhidot (IgM), a serological test to identify IgM antibodies against Salmonella typhi. The study was carried out in the department of Microbiology, Mymensingh Medical College, Mymensingh between June, 2006 and July, 2007, on a total of 100 samples from clinically suspected patients to have typhoid fever. Blood culture as well as Typhidot test were performed for each of the cases. Out of 100 clinically diagnosed typhoid fever, 14 were blood culture positive for S. typhi and 73 were Typhidot (IgM) positive. Among 14 culture positive cases, 13 (92.85%) were Typhidot (IgM) positive. The test was also positive in 04 (20%) out of 20 febrile controls. None of the healthy controls was positive by Typhidot (IgM). The sensitivity, specificity, positive predictive value and negative predictive value of the test using blood culture as gold standard were 92.85%, 90.00%, 76.47% and 97.29% respectively for typhoid fever. Typhidot (IgM) test is rapid, easy to perform and reliable test for diagnosing typhoid fever, and useful for small, less equipped laboratories as well as for the laboratories with better facilities. In the present study, 13 (92.85%) out of 14 culture-positive cases were positive for Typhidot (IgM). These results are consistent with the findings from Pakistan showing 43 (93.47%) Typhidot-positives out of 46 culture-positive typhoid fever cases, and in India, 35 (92.10%) out of 38 culture-positive cases were Typhidot positive.17,19 The only 01(7.14%) out of 14 culture-positive cases of the present study was negative in Typhidot (IgM), was a 3 years old child attended in the 2nd day of fever. The false negative Typhidot (IgM) in this case was probably due to the failure of the test to detect the antibodies or perhaps the antibodies did

Evaluation of Typhidot (IgM) for Early Diagnosis of Typhoid Fever