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Pregnancy is accompanied by profound alteration of thyroid economy and relative iodine deficiency. Sub-optimal thyroid function in pregnancy is associated with impaired neuro intellectual development. Urinary iodine concentration is increased during pregnancy. The aims of this study were to evaluate urinary iodine level in pregnant women and also to elucidate its correlation with thyroid parameters (TSHF the mean age of the pregnant and nonpregnant women were 25.03±0.48 yrs and 25.20±0.60 yrs respectively. No significant difference was found regarding age. The median urinary iodine of pregnant women was 438.13µg/l (range240.50-490.0) and that non pregnant women was 412.50µg/l (range 240.0-473.75µgl). Mean serum TSH were 1.29±0.15 and 1.97±0.18 mIU/L and mean serum FT4 were 14.51±0.41 and 16.30 ±0.41pmol/L in pregnant and non pregnant women respectively. Urinary iodine level was significantly increased in pregnant women compared to that of the non pregnant group (p<0.05). A significant negative correlation was found between urinary iodine and serum TSH (p<0.01) whereas a positive correlation between urinary iodine and serum FT4 level is p<0.05 in pregnant and p<0.01 in non pregnant group. Urinary iodine excretion is increased in pregnancy than that in non pregnant women. Clinically and biochemically all the subjects were euthyroid and excretion rate of iodine in all subjects were above the normal range. Bangladesh J Med Biochem 2015; 8(1): 21-26

Urinary Iodine Level in Healthy Pregnant Women and its Correlation with Serum TSH & FT4