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ORIGINAL ARTICLE Bangladesh J Med Biochem 2017; 10(1): 10-15 Introduction Preeclampsia is an idiopathic multisystem disorder specific to human pregnancy1. It is defined as the onset of hypertension and the presence of proteinuria during pregnancy, usually occurring after the 20th week of gestation in a previously normotensive woman and resolving completely by the sixth week after delivery of fetus2. Preeclampsia is a transient but potentially dangerous complication of pregnancy. Generally, the incidence of preeclampsia is in the range of 4-8% of all pregnancies3. The incidence of preeclampsia has fallen in developed countries due to improved antenatal care, but it's incidence is still high in the developing countries4, and preeclampsia accounts for about 20-80% of the maternal mortality in developing countries5. Preeclampsia and eclampsia cause about 16 % of maternal death in Bangladesh4. Despite of preeclampsia's prevalence and severity, the pathophysiology of this multisystem disorder is still poorly understood and it's etiology has not yet been fully elucidated. Environmental and nutritional factors may play a role in the development of preeclampsia6. The epidemiology of preeclampsia, being more common in poor women, long ago suggested that nutrients might be involved in the disorder7. It is Preeclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Reduced serum magnesium level is found to be associated with elevated blood pressure in preeclampsia. The purpose of this cross-sectional study is to evaluate the serum magnesium level in preeclamptic women. For this study 50 preeclamptic patients, with age range 20 to 40 years having gestational age range from 20 to 40 weeks and 50 age and gestational age matched normotensive pregnant women having no proteinuria were enrolled. Serum magnesium was measured by colorimetric method. The mean(±SD) age and mean(±SD) gestational age of preeclampsia was not significantly different from those of normotensive pregnant women (p=0.203 and p=0.251 respectively). The mean(±SD) body mass index of the preeclamptic patients was significantly higher compared to that of normotensive pregnant women (p<0.001). The mean(±SD) serum magnesium level was 3.37±2.05 mg/dl in preeclamptic group and 2.87±1.38 mg/dl in normal pregnant women; the level did not differ significantly between the subject of preeclampsia and normal pregnant women (p=0.153). Findings of this study suggest that serum magnesium has no association with preeclampsia.

Evaluation of Serum Magnesium Level in Preeclampsia