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Bleeding is a relatively common complication in patients with multiple myeloma. Different factors have been involved, such as heparin-like anticoagulants, although the underlying mechanism remains obscure. The identification of a patient with a quiescent multiple myeloma IgG-γ that suffered a

haematologica

Identification of a new potential mechanism responsible for severe bleeding in myeloma: immunoglobulins bind the heparin binding domain of antithrombin activating this endogenous anticoagulant