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Homeobox (HOX) transcription factors are important for the regulation of normal hematopoiesis. Many cases of acute myeloid leukemia (AML) are driven by aberrant expression of clustered HOX genes that is mediated by chimeric oncoproteins involving MLL, chromosomal translocations directly affecting

Widespread over-expression of the non-clustered homeobox gene HLX in acute myeloid leukemia