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We report, in a constitutionally heterozygous carrier of the sickle-cell trait, an abnormally low HbS level (12%) caused by a somatic deletion of the HBB gene (βS allele) that occurred presumably in an early precursor of the hematopoietic lineage.

HBB loss of heterozygosity in the hemopoietic lineage gives rise to an unusual sickle-cell trait phenotype