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We read with great interest the observation by Lukusa and Vermylen of 4 patients with Sickle Cell Disease (SCD), treated by hydroxyurea (HU) in childhood and displaying severe impairment of spermatogenesis.The adult male patients, in the series we have reported (Haematologica, 2008, 93:988–93),

Reply to: [Use of hydroxyurea from childhood to adult age in sickle cell disease: semen analysis. Haematologica 2008; 93:e67]