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such as levels of urinary sulfatides and leukocyte arylsulfatase A (only urinary arylsulfatase A was detected in the low range), or mutation analysis of the arylsulfatase A gene have not been reported in this case. The pathological description of the peripheral nerve disease is uncommon for MLD. The MRI lesions of both grey and white mat- ter, as described in this patient, are very unusual for adult MLD. Second, the report suggests that infusion of mes- enchymal stem cells was important for the engraftment and for improvement of the peripheral nerve dysfunc- tion. This is clearly a possibility, as suggested previously by Koc et al., 3 that warrants further investigations. Since the diagnosis of MLD is questionable, however, these results are not interpretable.

haematologica

Reply to: Reduced intensity conditioning haematopoietic stem cell transplantation with mesenchymal stromal cells infusion for the treatment of metachromatic leukodystrophy: a case report. Haematologica 2008; 93:e11-13