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In a previous paper, the substituted tetrahydropyrrolo[3,4c]pyrrole-1,3-dione (THPPD) has been presented as new potential colchicine site inhibitor discovered by in silico study. In this short note, the results of preliminary in vitro study are presented. Six of seven evaluated THPPD derivatives inhibited in vitro tubulin assembly. Further, two structurally different molecules, also resulting from molecular docking study, have been evaluated and proved to exhibit antitubulin activity.

In vitro evaluation of antitubulin of activity tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione derivatives