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Background: Vesiculo-bullous diseases are a group of chronic cutaneous disorders characterised by mucocutaneous blistering or erosions as a result of development of autoimmunity. Aims: To understand the pathophysiology of pemphigus vulgaris and the recent concepts of Pulse therapy with different modalities and their various actions on different tissue levels. Results &ConclusionPulse therapy can be a boon to stomatologists if understood with clarity and applied with precision. It can definitely create miracles in saving lives and help in the outcome of the prognosis of most of the autoimmune disorders.

PEMPHIGUS VULGARIS – PATHOPHYSIOLOGY AND RECENT CONCEPTS FOR PULSE THERAPY - A SYSTEMATIC REVIEW.