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Post translational modifications like phosphorylation, Glycosylation and ADP ribosylation serves as biomarkers and are mainly involved in regulation of signalling pathways, cell polarity and cell cycle progression. So, this review helps in finding the biomarkers in understanding of cancer genome and also the deviations observed in gating mechanisms. Mucin 3 is mainly involved in EMT transition and Phosphorylation is also required for effective complex formation between catenin and cadherin. Hyaluron acts as medium for the tumors cells and aids in their movement and responsible for metastatic development. Epigenetic modification like methylation is helpful for cancerous genome to develop additional mutations for survival of the genome.&#x0D;Key words: Cyclin D, PTMs, Gating, Glycosylation, Phosphorylation.

PTM AND CELL CYCLE GATING MECHANISMS DEVIATED FOR PROGRESSION OF CANCER