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Combined therapy with intravesical instillation of hydroxypropylcellulosedoxorubicin and local hyperthermia was performed in 11 patients with recurrent and multiple bladder carcinomas. The stage of the cancer before treatment was T1 in 4 cases, carcinoma in situ in 2 cases and T2 in 5 cases. Among the 11 cases, 7 cases had severe complications such as cardiac disease and pulmonary emphysema. Hydroxypropylcellulose-doxorubicin was instilled into the bladder, and then local hyperthermia was applied by means of capacitive heating using Thermotron RF-8. Therapeutic effect was as follows: complete response in 6 cases, partial response in 4 cases, and no response in 1 case. All 11 cases are alive as of this report with a survival duration ranging from 8 to 45 months. Adverse effects seen were induration of subcutaneous fatty tissue in 5 cases and first degree burns in 2 cases. There was no systemic adverse effect in the 11 patients treated.

Effects of Combined Treatment with Local Hyperthermia and Intravesical Instillation of Hydroxypropylcellulose-doxorubicin on Recurrent Bladder Cancer.