English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Recently, we have reported the cloning and characterization of a novel protein, Nischarin that associates with α 5 integrin in vitro and in vivo. Nischarin appears to have a negative regulatory function in cell migration by antagonizing the actions of Rho GTPases on cytoskeletal organization and cell movement. I now report chromosomal localization of the gene for mouse Nischarin. Fluorescence In Situ Hybridization (FISH) analysis of metaphase chromosomes derived from mouse embryo fibroblast cells revealed that Nischarin is local- ized to chromosome 3. Also further labeling of the te- lomere and middle portion of chromosome 3 indicated that the gene position is 53% of the distance from the heterochromatic boundary to the telomere of chromo- some 3, corresponding to 3F1-F2-1. Mouse chromo- some 3 seems to share a region of homology with the human chromosome 3, however the homologous genes mapped so far are all on human 3q. Interestingly, the human homolog of Nischarin has been mapped to chro- mosome 3p. The possibilities for this conundrum between human and mouse genomes are also discussed.

Mapping of the gene for Nischarin, a Novel Integrin Binding Protein, to Chromosome 3 by Fluorescence In Situ Hybridization