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Obesity-associated with several chronic diseases. Based on this condition, natural products use should be considered as an alternative treatment. The objectives of this research are to evaluate the effect of senna (Senna alexandrina Mill.) and pomegranate (Punica granatum L.) leaves extracts and its fractions on pro-inflammatory cytokines suppression of the obese zebrafish. Methods: acclimatization period was performed for two weeks. All zebrafish was given by standard diet intake. Post acclimatization, zebrafish were divided into 10 groups (n = 15 in each group) including normal group; obese group; senna extract group (SE) 100μg/ml; pomegranate extract group (PE) 100μg/ml; senna fractions groups [(n-hexane fraction (HFS) 50μg/ml, ethyl-acetate fraction (EFS) 50μg/ml, and water fraction (WFS) 50μg/ml], and pomegranate fractions groups [(n-hexane fraction (HFP) 50μg/ml, ethyl-acetate fraction (EFP) 50μg/ml, water fraction (WFP) 50μg/ml]. For a period of 4 weeks, the normal group was given by a normal diet and other groups by a high-fat diet. Obese group was given by 240 mg/group/fish of the experimental diet. Gene expression analysis was performed using quantitative Real-Time Polymerase Chain Reaction method. Results: The results of this study showed that both senna and pomegranate leaves extracts and its fractions have ability to suppress pro-inflammatory cytokines (such as TNF-α, IL-1β, leptin and increased anti-inflammatory cytokine (such as IL-10) of high-fat diet-induced obese zebrafish. Conclusion: senna and pomegranate leave extracts and its fractions have a potential effect and very promising to suppress pro-inflammatory cytokines and increased anti-inflammatory cytokines of high-fat diet-induced obese zebrafish.

rasayan journal of chemistry/rasayan journal of chemistry

EFFECT OF SENNA (Senna alexandrina Mill.) AND POMEGRANATE (Punica granatum L.) LEAVES EXTRACTS AND ITS FRACTIONS ON PRO-INFLAMMATORY CYTOKINES OF THE OBESE ZEBRAFISH (Danio rerio)