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Background: In the modern era of critical care management, sepsis remains a serious problem accounting for thousands of death per year with noteworthy morbidity and mortality. Sepsis results in multi-organ dysfunction secondary to culture-positive or negative infection. In diabetes mellitus (DM), the major problem is vurnerable infection or sometimes development of sepsis and septic shock. Researchers showed DM has reduced bacterial clearance as hyperglycemia decreases polymorphonuclear function and less production of inflammatory cytokines. Thus DM creates a comorbid condition in sepsis. The mechanism of the inter-twining of diabetes, infection and inflammatory response in sepsis is quite unclear. Research methods: Our objective remains in clarifying the reliability of acute phase biomarkers as diagnostic tool (Procalcitonin; PCT and C-reactive protein; CRP) in diabetic patient in comparison to non-diabetic patients with sepsis. A total of 40 subjects, (20 patients had sepsis with DM, 20 patients had sepsis without DM) were enrolled. PCT, CRP, and other laboratory testing (WBC count, ESR, serum lactate, albumin) were done for all subjects at admission. Subjects were managed according to hospital protocol and followed up till remedy. Acute phase biomarker status was assessed based on their stratified concentration in groups. Results: Compared with non-DM group, PCT and CRP in DM group were significantly high (all P < 0.05) and associated with bad outcome. Conclusion: PCT level ( 40 ng/mL; odds ratio 1) and CRP level (100 mg/L; odds ratio 1) proved to be a reliable acute phase marker of sepsis patients with DM in Indian population.

ROLE OF ACUTE PHASE REACTANTS: STUDY IN DIABETIC AND NON DIABETIC PATIENTS SUFFERING FROM SEPSIS IN INDIA