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Fibrinolysis refers to the natural enzymatic system responsible for dissolving a blood clot or thrombus.  Since an intravascular thrombus is responsible for almost all heart attacks and most strokes, interest in fibrinolysis, the only medical treatment, dominated medical interest in the 60’s-90’s.  Since that time, the incidence of heart attacks and strokes has not changed much, but interest in fibrinolysis has faded.  Instead, interest has shifted to catheter removal of clots, called percutaneous coronary intervention (PCI) which is a time-consuming that delays reperfusion considerably, and is much more costly than fibrinolysis.   It is also a cruder treatment that can only remove clots larger than the catheter, but it is very well reimbursed.

How Fibrinolysis was Defeated by PCI