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The lipids molecules translocation in phospholipid membrane is named the (flip-flop) event.   For this purpose, the translocation may take place in vivo with the surface of articular cartilage. Flip-flops are one of the least understood dynamical processes in vivo in cartilage membranes.    In this work, we explain the molecular mechanism lipid translocation (flip-flop) in vivo during the drying process cartilage surface.  Wettability of cartilage surface vs. drying time was determined.  Our findings strongly support the idea that the process of translocation lipid (flip-flop) transformed hydrophilic surface in hydrophobic in dry-air condition for healthy and osteoarthritic cartilage.  Such material can be classified cartilage as “smart material” and this fact is poorly known in the literature.

Lipid Translocation (Flip-Flop) As One of the Least Understood Dynamical Processes in Articular Cartilage Membrane