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Many molecular markers have been identified in different stages of the luteal phase those play roles in the implantation. Our aim was to compare the levels of insulin-like growth factor binding protein 1 (IGFBP-1), Osteopontin (OPN) and prostaglandin E2 (PGE2) in endometrial washing liquid between women with ovulatory polycystic ovary syndrome (PCOS), endometrioma and unexplained subfertility, compared with ovulatory women. The study groups were formed by women with ovulatory PCOS (n=24), endometrioma (n=17) and unexplained subfertility (n=25). The control group consisted of fertile women (n=18). There were no significant differences in terms of the values of IGFBP1, PGE2 and OPN among groups. There was a statistically significant difference between ovulatory PCOS group and control group in terms of PGE2 levels (p=0.002). High PGE2 might be a marker for poor endometrial receptivity. We supposed that the down-regulation of PGE2 may facilitate decidualization and improve pregnancy rate in ovulatory PCOS.

journal of obstetrics gynecology and reproductive sciences

Endometrial Receptivity Markers In Patients With Ovulatory Polycystic Ovary Syndrome, Endometrioma And Unexplained Subfertility: A Prospective Comparative Study