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The aim of the study was to analyze the phospholipase, proteinase and hemolysis of Candida albicans isolated from the oral cavity of HIV positive individuals and to evaluate the influence of antirretroviral therapy with protease inhibitors (PI) on enzymatic production. Twenty five C. albicans isolates obtained from oral swabs of patients with HIV were studied. For testing the production of proteinase, phospholipase and hemolise, the culture media containing bovine albumin, egg yolk and blood were used, respectively. Nineteen (76%) of isolates showed proteinase activity. All C. albicans strains that were studied produced phospholipase and hemolysins. No statistically significant difference was found in the intensity of the activity of the exoenzymes in isolates from patients using PI in relation to those who did not use these antivirals, suggesting that PI not reduce in vitro the secretion of these enzymes by C. albicans. The high production of the proteinase, phospholipase and hemolysins evidences the potential pathogenic power of these isolates. Descriptors: Candida albicans; Virulence factors; Protease inhibitors.

Fatores de Virulência de Candida albicans Isoladas da Mucosa Oral de Pacientes HIV Positivo