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Background: Myxoma is a rare tumor most frequently discovered in cardiac locations. The present report describes a rare case of extracardiac origin in the femoral vein, initially presenting as leg pain and swelling.Case Presentation: A 40-year-old woman was admitted to our regional hospital with unilateral left leg swelling and pain. She underwent a Duplex scan and CT scan, which revealed a 21 x 25 mm diameter mass in contact with the distal femoral vein, initially diagnosed as a thrombosed sacciform aneurysm. The patient underwent surgical excision of a bulging mass in the vein wall, which was directly closed by running suture. The anatomopathological report concluded with a myxoma. One-year follow-up showed a patent vein without evidence of recurrence of the tumor.Conclusion: Although very rare, peripheral venous myxoma may manifest with common symptoms as leg pain and swelling. Current vascular imaging and complete surgical excision should be performed without delay to allow a precise diagnosis and prevent further complications.

Venous Myxoma of the Distal Femoral Vein: A Rare Case of Leg Pain and Swelling