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v CHAPTER 1. GENERAL INTRODUCTION 1 Dissertation Organization 2 Literature Cited 2 CHAPTER 2. REVIEW OF LITERATURE 3 History of Mitochondrial Research 3 Mitochondria Structure and Function 6 Energy Use in the Whole Body 11 Inefficiencies in Mitochondrial Energy Production 14 Control of Mitochondrial Energy Production 21 General Summary 28 Literature Cited 29 CHAPTER 3. QUANTITATIVE RELATIONSHIP BETWEEN MITOCHONDRIAL FUNCTION AND EFFICIENCY OF ANIMAL GROWTH 38 Abstract 38 Introduction 39 Materials and Methods 40 Results and Discussion 43 Implications 49 Literature Cited 49

Relationship of mitochondrial energy production with the rate and efficiency of whole body growth in young growing animals