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Chapter 1: Introduction On the nature of viruses Virus physiology and nomenclature Baculoviridae The host and viral immunity Baculovirus occlusion derived virus (ODV) Receptor binding and fusion Thesis organization References Chapter 2: ODV-E56 is PIF-8 and is non-essential to binding and fusion ABSTRACT BACKGROUND MATERIALS AND METHODS RESULTS DISCUSSION AUTHOR CONTRIBUTIONS ACKNOWLEDGEMENTS REFERENCES TABLES AND FIGURESBACKGROUND MATERIALS AND METHODS RESULTS DISCUSSION AUTHOR CONTRIBUTIONS ACKNOWLEDGEMENTS REFERENCES TABLES AND FIGURES Chapter 3: A peptide that binds the gut epithelium of Heliothis virescens has similarity to the baculovirus envelope protein ODV-E66 and impedes infection with wild type baculovirus SUMMARY INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS ACKNOWLEDGEMENTS REFERENCES TABLES AND FIGURES Chapter 4: Discussion and Conclusions REFERENCES

Interaction of the baculovirus occlusion-derived virus envelope proteins ODV-E56 and ODV-E66 with the midgut brush border microvilli of the tobacco budworm, Heliothis virescens (Fabricius)