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Human	  Immunodeficiency	  Virus	  type	  1	  (HIV-­‐1)	  is	  a	  highly	  variable	  virus	  that continues	  to	  cause	  a	  worldwide	  pandemic.	  The	  search	  for	  a	  vaccine	  has	  focused	  on	  the elicitation	  of	  broadly	  neutralizing	  antibodies	  (bnAbs),	  which	  can	  prevent	  the	  attachment and/or	  entry	  of	  the	  majority	  of	  HIV	  strains.	  In	  this	  thesis,	  we	  attempt	  to	  elicit	  more common	  neutralizing	  antibodies	  (nAbs),	  which	  are	  type-­‐specific	  in	  their	  ability	  to	  block HIV	  infection.	  However,	  we	  propose	  to	  elicit	  a	  wide	  range	  of	  these	  type-­‐specific	  nAbs	  to mimic	  the	  breadth	  of	  protection	  found	  in	  true	  bnAbs	  to	  protect	  the	  host	  from	  multiple HIV	  strains.	  We	  immunized	  both	  mice	  and	  rabbits	  with	  a	  twelve	  virus	  panel,	  termed global	  panel,	  that	  represents	  seven	  different	  HIV-­‐1	  clades.	  The	  immunizations	  were performed	  using	  particle	  mediated	  epidermal	  delivery	  (PMED)	  loaded	  with	  plasmids that	  could	  express	  the	  desired	  env	  proteins	  in	  vivo.	  The	  mice	  did	  not	  elicit	  any neutralizing	  activity	  against	  tier	  1	  or	  tier	  2	  viruses.	  The	  rabbits	  had	  neutralization	  against one	  of	  the	  tier	  1	  viruses	  tested,	  but	  not	  against	  any	  of	  the	  tier	  2	  global	  panel	  viruses.

Antibody response of mice and rabbits targeting HIV-1 using global panel DNA and SOSIP gp140 protein