English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Lymphatic Filariasis (LF) is a Neglected Tropical Disease, caused by mosquitoborne filarial nematodes including Brugia malayi, which infects over 120 million people. Mass drug administration is used for LF control but limited efficacy of the drugs combined with the threat of resistance drives the need for novel control strategies. Chemosensation is an essential behavior used by nematodes, including parasitic species, has roles in development, avoidance of noxious stimuli and finding food/mates/hosts, making genes involved in this system attractive targets for parasite control. Little, however, is known about the chemosensory system in parasitic nematodes. Here we address this knowledge gap and describe the structural, behavioral and genetic basis for chemosensation in filarial nematodes. Sensory structures and their innervation are identified in larval and adult stages of B. malayi using scanning electron and fluorescent microscopy. In addition, behavioral responses of B. malayi L3 stage parasites to hostderived stimuli were profiled and specific tactic behaviors that may be important in hostseeking and host-invasion identified. To further characterize the genetic basis for chemosensation in B. malayi, we surveyed heterotrimeric G-proteins (known mediators of nematode chemosensation) on a pan-phylum level using bioinformatic and phylogenetic approaches. This analysis revealed highly conserved and novel patterns of gene expression that may be exploited for novel LF control strategies. While the characterization of chemosensation in B. malayi has revealed one mechanism by which the nematode interacts with its environment, interactions between the nematode and host (both mosquito and human) are far more complex. Here we also present results, which demonstrate for the first time that parasitic nematodes of humans use exosomes, a

Mechanisms of communication in the filarial worm, Brugia malayi, at the mosquito vector-mammalian host interface