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vi CHAPTER 1: GENERAL INTRODUCTION 1 1.1 Membrane fusion and exocytosis 1 1.2 SNAREs 1 1.3 SNARE-mediated neuroexocytosis 3 1.4 Regulation of neurotransmitter release 4 1.4.1 Synaptotagmin-14 1.4.2 Sec1/Munc18-1 (SM) protein family 5 1.4.3 Complexin-1  6 1.5 Investigation apparatus 7 1.5.1 Nanodisc as a model membrane: reconstitution of a single membrane protein 7 1.5.2 Site-directed spin labeling (SDSL) and electron paramagnetic resonance (EPR) 8 1.5.3 Single molecular fluorescence (Förster) resonance energy transfer (smFRET) 9 1.6 References 11 1.7 Figures and Legends 19 CHAPTER 2: MULTIPLE CONFORMATIONS OF A SINGLE SNAREPIN BETWEEN TWO NANODISC MEMBRANES REVEAL DIVERSE PRE-FUSION STATES 34 2.1 Abstract 34 2.2 Introduction 35 2.3 Results 36 2.3.1 Reconstitution of the SNAREpin into two nanodiscs 36

Investigation of SNARE-mediated exocytosis controlled by synaptic regulatory proteins