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Background:	 Iliotibial	 band	 syndrome	 (ITBS)	 is	 the	 leading	 cause	 of	 lateral knee	 pain	 in	 runners.	 Previous	 research	 has	 theorized	 that	 higher	 ITB	 strain	 rate leads	 to	 ITBS	 development.	 Orthotics	 are	 commonly	 used	 to	 correct	 gait	 mechanics and	 may	 reduce	 ITB	 strain	 and	 strain	 rate.	 The	 purpose	 of	 this	 research	 was	 to investigate	 how	 wedge	 inserts	 and	 gender	 affect	 kinematics,	 kinetics,	 and	 ITB	 strain and	 strain	 rate	 during	 running.	 Methods:	 Thirty	 (15	 male,	 15	 female)	 participants ran	 with	 lateral	 7°,	 lateral	 3°,	 no	 wedge,	 medial	 3°,	 and	 medial	 7°	 wedges.	 A	 motion capture	 system	 and	 force	 platform	 were	 used	 to	 collect	 kinematic	 and	 kinetic	 data. Joint	 angles	 and	 joint	 moments	 were	 calculated	 during	 the	 stance	 phase.	 ITB	 strain and	 strain	 rate	 were	 determined	 using	 a	 six	 degree	 of	 freedom	 musculoskeletal model.	 Findings:	 There	 were	 no	 significant	 differences	 for	 ITB	 strain	 or	 strain	 rate between	 wedge	 conditions	 or	 genders.	 The	 lateral	 7°	 wedge	 resulted	 in	 significantly higher	 ankle	 eversion	 angles	 and	 lower	 ankle	 plantar	 flexion	 moments	 than	 no wedge.	 The	 medial	 7°	 wedge	 resulted	 in	 significantly	 lower	 ankle	 eversion	 angles, higher	 hip	 internal	 rotation	 angles,	 lower	 ankle	 plantar	 flexion	 moments,	 lower ankle	 inversion	 moments,	 and	 higher	 external	 knee	 varus	 moments.	 Males	 had significantly	 higher	 knee	 valgus	 angles,	 knee	 internal	 rotation	 angles,	 ankle	 plantar flexion	 moments,	 ankle	 inversion	 moments,	 and	 knee	 extension	 moments. Interpretation:	 Results	 indicate	 that	 wedge	 inserts	 do	 not	 have	 a	 significant	 effect upon	 ITB	 strain	 and	 strain	 rate	 for	 healthy	 runners.	 While	 wedge	 orthotics	 may correct	 ankle/foot	 alignment	 problems,	 higher	 external	 knee	 varus	 moments	 with	 a medial	 7°	 wedge	 are	 of	 concern.

The effects of medial and lateral wedges on iliotibial band strain during overground running