English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive disorder in breeding pigs and respiratory symptoms in pigs of all ages. The virus continues to bring significant economic losses to swine industry, and is considered to be one of the most important swine pathogens. Vaccination has been utilized to aid or facilitate PRRS control. Among various types of vaccines used, attenuated live virus vaccines appear to be more efficacious than killed virus vaccines. However, the effect of vaccination with attenuated live virus vaccines is crippled by several safety and efficacy issues. First, the vaccine development process is time-consuming. Second, the vaccine has the potential to revert to virulent. Third, the vaccine tends to provide full protection only to homologous strains. Three independent studies were conducted to address these issues and provide a concept for future vaccine development. The first study was based on a previous in vitro work in our laboratory which demonstrated that chimeric viruses containing mixed structural genes from two genetically and antigenically distinct strains (VR2332 and JA142) of PRRSV in an organized manner were susceptible to antisera generated against both of the donor strains. In the present study, three chimeric viruses (JAP5, JAP56 and JAP2-6) were constructed by replacing ORF5, ORFs 5 and 6, and ORFs 2-6 of VR2332 with the corresponding gene(s) of JA142 respectively and were evaluated in vivo for their ability to confer pigs the cross protection against the VR2332 and JA142 strains. A total of 114 pigs were divided into 6 groups and each group was intramuscularly inoculated with one of the three chimeric viruses (n=16 per group), VR2332 (n=24), JA142 (n=24), or sham inoculums (n=18). At 44 days post

Utilities of reverse genetics system as a platform for the development of Porcine Reproductive and Respiratory Syndrome (PRRS) virus vaccine