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The A potential mechanism by which highly pathogenic avian influenza H5N1 viruses could become established in humans would be through the infection of and adaptation in pigs. To detect the occurrence of such adaptation, monitoring of the pig populations in endemic H5N1 areas, potentially through serological screening, would be necessary. In the current study, we determined that the hemagglutination inhibition assays would have limited ability to detect antibodies against H5N1 developed in pigs, primarily because the use of multiple virus strains would be required. We developed

Advances in understanding influenza A virus infection in swine: From diagnostics to basic science