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iv CHAPTER 1. GENERAL INTRODUCTION Introduction to the Dissertation 01 Literature Review: Influenza viral infection 01 Immune response to influenza infection 08 Immunosenescence 25 Exercise and the Immune System 37 CHAPTER 2. AGE IMPAIRS INNATE IMMUNE RESPONSE TO INFLUENZA INFECTION IN MICE. Abstract 40 Introduction 41 Materials and Methods 44 Results 47 Discussion 53 Figures 57 References 86 CHAPTER 3. MODERATE EXERCISE REDUCES VIRAL LOAD AND ALTERS INNATE IMMUNE RESPONSE TO INFLUENZA INFECTION IN AGED MICE. Abstract 90 Introduction 91 Materials and Methods 94 Results 99 Discussion 100 Figures 104 References 119

Immunosenescence and exercise-mediated modulation of the innate immune response to Influenza infection in mice