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The characteristic lesion in bovine tuberculosis is well-organized respiratory granulomas. This is typically associated with a strong T-helper 1 (Th1) biased cell- mediated immune response and eventual containment of the infection. In bovine paratuberculosis, the classic lesion is unorganized granulomatous intestinal inflammation. Clinical paratuberculosis is associated with a T-helper 2 (Th2) biased humoral immune response and eventual death due to inability of the host to contain the infection. Recent reports have suggested that gamma-delta  T cells play a significant role in granuloma development and/or maintenance during initial stages of infection and may influence the

Modeling the initial host immunopathologic response to Mycobacterium avium subspecies paratuberculosis infection in young cattle