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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi CHAPTER 1. General Introduction . . . . . . . . . . . . . . . . . . . . . . . . 1 1.

Estimating the number of true null hypotheses and the false discovery rate from multiple discrete non-uniform permutation p-values